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The bacteria have developed resistance against many of the drugs available in the market. Halgamuge "Self-Organizing Hierarchical Particle Swarm Optimizer With Time Varying Acceleration Coefficients" IEEE Trans. A well organized research comprising of analogue based drug design and molecular dynamics plays a major role in obtaining the lead molecules. Black PN, Di Russo CC, Metzger AK, Heimert TL (1992): Cloning, sequencing, and expression of the fad D gene of Escherichia coli encoding Acyl coenzyme A Synthetase. Krus, "On Load Sensing Fluid Power Systems," Division of Fluid Power Control Department of Mechanical Engineering, Linkoping University, Sweden, 1988. Palmberg, "Hydraulic transformers-comparison of different designs," 2004. Abstract: Particle swarm optimization (PSO ) is an effective & reliable evolutionary based approach . Yuhui Shi and Russell Eberhart "A modified particle swarm optimizer" 0- 7803-4869-9198 0.0001998 IEEE. A new hydraulic system was proposed as a solution to relieve the hydraulic resistance in the actuators. The proposed system is a four ports hydraulic cylinder fitted with a novel flow control valve. Goldenberg, "Design of a new high performance electrohydraulic actuator," in Proceedings of The International Conference on Advanced Intelligent Mechatronics, IEEE/ASME,, 1999, pp.
(April 2003), "Nanometer stepping drives of surface acoustic wave motor", IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 50, IEEE, pp. Due to its higher quality solution including mathematical simplicity, fast convergence & robustness it has become popular for many optimization problems. Results show that the hydraulic resistance is significantly reduced in the proposed four ports actuators; and the proposed cylinders run faster than the conventional cylinders and a considerable amount of energyis saved as well. Key words: Computational Hydraulic, Energy Efficient Actuators, Energy Saving in Hydraulic, Hydraulic Control Reference  P. Adhinarayanan, Maheswarapu Sydulu "Particle Swarm Optimisation for Economic Dispatch with Cubic Fuel Cost Function", TENCON 2006, IEEE region conference. Acyl Co A Synthetase is an enzyme that participates in fatty acid biosynthesis. The performance of proposed cellular genetic algorithms is examined under three dynamic optimization problems with different change severities.
Most of the genes are involved in biosynthetic and metabolic pathways, so the product of these genes can be aimed for the novel drug target. Transmembrane movement of exogenous long-chain fatty acids: proteins, enzymes, and vectorial esterification. Moreover, in the second proposed rule, the competition scheme of the best individuals within the neighborhoods of one individual is also introduced. Key words: docking, homology modeling, leprosy, M.leprae, molecular, molecular dynamics, ramachandran plot.